Fluctuation of c-fos like immunopositive structure in pentylenetetrazol kindling formed mouse brains.
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چکیده
منابع مشابه
Suppression of Pentylenetetrazol-Induced Seizures and c-fos Expression in Mouse Brain by L-Carnitine
Suppression of PentylenetetrazolInduced Seizures and c-fos Expression in Mouse Brain by L-Carnitine: Yoshihisa IRYO, et al. Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health—Seizure development in ddY mice was recorded on a videotape for 20 min after injection of pentylenetetrazol (PTZ) (50 mg/kg) and analyze...
متن کاملPiracetam prevents pentylenetetrazol kindling-induced neuronal loss and learning deficits
The effect of the nootropic drug piracetam (100 mg/kg) on kindled seizures, kindling-induced learning deficits, and histological alterations due to changes in central excitability was investigated in Wistar rats. The animals were kindled by repeated i.p. injections of an initially subconvulsive dose of pentylenetetrazol (PTZ). As a control, piracetam or physiological saline was given 60 minutes...
متن کاملNull mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy.
It has been suggested that expression of the immediate early gene c-fos links fleeting changes in neuronal activity to lasting modifications of neuronal structure and function in the mammalian nervous system. To test this idea, we examined behavioral and electrophysiological indices of kindling development and kindling-induced sprouting of hippocampal granule cell axons in wild-type (+/+), hete...
متن کاملExpression of the proto-oncogene c-fos following electrical kindling in the rat.
Kindling is a permanent form of brain change that results from repeated elicitation of epileptiform neural activity. c-fos has been proposed as the gene responsible for turning on molecular events that might underlie the long-term neural changes that occur during kindling. This study investigated the enhancement of c-fos levels following kindled seizures and the role of c-fos in the plastic cha...
متن کاملPentylenetetrazol-kindling induced synaptic plasticity in the CA1 region of rat hippocampus
The impact of pentylenetetrazol-induced kindling on the effectiveness of theta pattern primed-bursts (PBs) for the induction of long-term potentiation (LTP) of field excitatory postsynaptic potentials (fEPSP) and population spikes (PS) were investigated in hippocampal CA1 of pentylenetetrazol-kindled rats in vivo. The results showed that shortly after kindling, control animals had normal LTP of...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1994
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.25.287